Mitochondrial Fusion Protein Mfn2 and Its Role in Heart Failure
نویسندگان
چکیده
منابع مشابه
Interplay of Mitochondrial Biogenesis and Oxidative Stress in Heart Failure Running title: Cooper; Role of mitochondrial biogenesis in heart failure
f iversity of Ma as s ssac ac a hu hu huse se sett tt tts s s 2 The dawn of mitochondrially powered cells began 1-2 billion years ago when an amitochonriate host subsumed Į-Proteobacterium, a hydrogen-producing symbiont 1. Equipped to oxidize nutrients, eurkaryotic cells acquired a 'boost' to cellular energy, enabling the emergence of multi-cellular mammals, sustained by a nearly inexhaustible ...
متن کاملMitochondrial dysfunction in heart failure.
angina was reached. Angina, unfortunately, is a subjective measure. Irrespective of how “objective” the investigators were in determining the success or failure of antianginal therapy, the use of a subjective end point may have inadvertently introduced bias into the trial. It is difficult to draw proper conclusions from such a trial when large crossover rates are allowed. With respect to the Eu...
متن کاملMitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development
Mitochondrial morphology is determined by a dynamic equilibrium between organelle fusion and fission, but the significance of these processes in vertebrates is unknown. The mitofusins, Mfn1 and Mfn2, have been shown to affect mitochondrial morphology when overexpressed. We find that mice deficient in either Mfn1 or Mfn2 die in midgestation. However, whereas Mfn2 mutant embryos have a specific a...
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15 صفحه اولComplementation between mouse Mfn1 and Mfn2 protects mitochondrial fusion defects caused by CMT2A disease mutations
Mfn2, an oligomeric mitochondrial protein important for mitochondrial fusion, is mutated in Charcot-Marie-Tooth disease (CMT) type 2A, a peripheral neuropathy characterized by axonal degeneration. In addition to homooligomeric complexes, Mfn2 also associates with Mfn1, but the functional significance of such heterooligomeric complexes is unknown. Also unknown is why Mfn2 mutations in CMT2A lead...
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ژورنال
عنوان ژورنال: Frontiers in Molecular Biosciences
سال: 2021
ISSN: 2296-889X
DOI: 10.3389/fmolb.2021.681237